According to experts, antibodies from llamas could help humans combat COVID-19.
A small antibody generated by llamas could be used to treat COVID-19 in the future.
The discovery was credited to a llama named Fifi by British researchers.
These llama nanobodies, which are also produced by camels, might potentially be created in a lab and delivered through nasal spray, attaching closely to the COVID-19 virus and neutralizing it, according to the researchers.
According to the study’s authors, utilizing antibodies from human patients who have recovered from the virus looks to be a more straightforward solution. Human antibodies are usually given as an infusion in a hospital environment.
Ray Owens, chief of protein production at the Rosalind Franklin Institute in England, remarked, “Nanobodies have a variety of benefits over human antibodies.”
“They are less expensive to make and can be delivered directly to the airways via a nebulizer or nasal spray, so they can be self-administered at home rather than requiring an injection,” Owens said in a press release from the institution.
“This could assist patients in terms of ease of use, but it also gets the therapy to the infection site in the respiratory tract,” Owens explained.
The study has “major potential for both the prevention and treatment of COVID-19,” according to Public Health England. The nanobodies are stated to be “among the most effective [COVID-19] neutralizing agents we have ever tested,” according to the study.
To conduct the study, the researchers injected a piece of the COVID-19 spike protein into Fifi, a member of the University of Reading’s antibody manufacturing facility.
The spike protein, which is found on the exterior of the COVID-19 virus, attaches to human cells and allows the virus to infect them.
The injections prompted Fifi’s immune system to produce nanobodies to combat the infection.
Fifi was then given a blood sample by the researchers. To improve their ability to connect to the virus, they purified four nanobodies and combined them into chains of three. These were then manufactured in laboratory cells.
The virus’s original forms, as well as the Alpha variant, were neutralized by three nanobody chains. The Beta version was neutralized by a fourth nanobody chain.
The researchers also gave hamsters infected with the virus one of the nanobody chains, known as a trimer. After seven days, the hamsters showed less illness, less weight loss, and a lower viral load in their lungs and airways than… Article Summary from Nokia News